Hygiena 2007, 52(3):70-72

Health Impact of Traffic Emissions

Vladimír Bencko1, Milan Tuček2, Jitka Petanová3, Ladislav Novotný1
1 Ústav hygieny a epidemiologie,
2 Klinika nemocí z povolání a
3 Ústav imunologie a mikrobiologie, 1. LF UK a VFN, Praha

Alterations of immunity due to exposure to traffic emissions may result in an increased risk of cancer.

Methods: Repeated observation of a total of 221 persons (84% men) for a period of three years consists of 44 persons occupationally exposed to polycyclic aromatic hydrocarbons (PAHs) and 117 healthy controls. The measurement of the content of 16 PAHs employing active personal dosimetry in the working air was performed by personal long-term sampling was done in 25 exposed persons. The exposure biomarker analyzed was the urine content of 1-hydroxypyrene (1-OHP).

Results: The monitored sums of PAHs in the working air ranged from 0.11 to 8.96 μg.m-3 and the mean values of the content of urine 1-OHP [μg.g-1 creatinine] in exposed persons and controls were found 0.56±1.04 and 0.08±0.08 respectively. The corresponding medians were 0.10 and the suggested limit for 1-OHP in urine (3.76) proved to be exceeded only in one individual from the exposed group. The life-time risk of carcinogenic effects was assessed to be in the range of 7.2 x 10-6 to 7.5 x 10-6. The effects of various external factors (such as the smoking habit) on tumor markers, immunity and cytogenetics were negligible.

Conclusion: The examined cohort may be considered to be exposed to genotoxic factors of low significance.

Keywords: occupational exposure, exhaust fumes, polycyclic aromatic hydrocarbons, health aspects

Published: September 2007  Show citation

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Bencko V, Tuček M, Petanová J, Novotný L. Health Impact of Traffic Emissions. Hygiena. 2007;52(3):70-72.
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